Faculty

Dr. Sergio Ruiz Macias received his Ph.D. in cell and molecular biology from the Complutense University in Madrid in 2004. As part of his postdoctoral training, he first joined the laboratory of Dr. Juan Carlos Izpisua-Belmonte at the SALK Institute in 2007 and then, as staff scientist in 2012, the group led by Dr. Oscar Fernandez-Capetillo at the Centro Nacional de Investigaciones Oncológicas (CNIO) in Madrid, where he developed his interests in embryonic stem cell biology and CRISPR/Cas9-based screens. He was then recruited to the NIH at the Laboratory of Genome Integrity, NCI, in June 2018 as part of the Earl Stadtman Investigator recruitment program.

• Cristina Mayor-Ruiz, Teresa Olbrich, Matthias Drosten, Emilio Lecona, Maria Vega-Sendino, Sagrario Ortega, Orlando Dominguez, Mariano Barbacid, Sergio Ruiz and Oscar Fernandez-Capetillo. (2018) ERF deletion rescues RAS deficiency in mouse embryonic stem cells. Genes & Development.doi:10.1101/gad.310086.117.
• Teresa Olbrich, Cristina Mayor-Ruiz, Maria Vega-Sendino, Carmen Gomez, Sagrario Ortega, Sergio Ruiz, and Oscar Fernandez-Capetillo. (2017) A p53-dependent response limits the viability of mammalian haploid cells. Proc Natl Acad Sci U S A.114 (35) 9367-9372; https://doi.org/10.1073/pnas.1705133114.
• Sergio Ruiz, Cristina Mayor-Ruiz, Vanesa Lafarga, Matilde Murga, Maria Vega-Sendino, Sagrario Ortega, Oscar Fernandez-Capetillo. (2016) A genome-wide CRISPR screen identifies CDC25A as a determinant of sensitivity to ATR inhibitors. Molecular CellVolume 62, Issue 2, Pages 307-313; https://doi.org/10.1016/j.molcel.2016.03.006
• Sergio Ruiz, Andres J. Lopez-Contreras, Mathieu Gabut, Rosa M. Marion, Paula Gutierrez-Martinez, Sabela Bua, Oscar Ramirez, Iñigo Olalde, Sara Rodrigo-Perez, Han Li, Tomas Marques-Bonet, Manuel Serrano, Maria A. Blasco, Nizar N. Batada & Oscar Fernandez-Capetillo. (2015) Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells. Nature CommunicationsArticle number: 8036.
• Sergio Ruiz, Dinh Diep, Athurva Gore, Athanasia D. Panopoulos, Nuria Montserrat, Nongluk Plongthongkum, Sachin Kumar, Ho-Lim Fung, Alessandra Giorgetti, Josipa Bilic, Erika M. Batchelder, Holm Zaehres, Natalia G. Kan, Hans Robert Schöler, Mark Mercola, Kun Zhang, and Juan Carlos Izpisua Belmonte. (2012) Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A.109 (40) 16196-16201; https://doi.org/10.1073/pnas.1202352109.

• Postdoctoral Fellow