Post date: 04/17/19
Our current research interests are focused on the mechanism by which Eph receptor tyrosine kinases and their ephrin ligands signal events affecting cell-cell adhesion and morphogenetic movements. From the elucidation of these signal transduction pathways we may improve our understanding of oncogenesis. The cell-cell adhesion system plays a major role in normal development and morphogenesis. Inactivation of this adhesion system is thought to play a critical role in cancer invasion and metastasis. The Xenopus embryo is well suited for investigations of these processes because the frog has a well characterized and invariant cell fate map and cell lineage can be easily traced during experiments. Mutant receptors, ligands, and other proteins can be ectopically expressed in embryos. Thus, their effects on signal transduction, motility, and differentiation can be assessed morphologically and histologically as well as biochemically in a developing vertebrate. Members of the Eph family have been implicated in regulating numerous developmental processes, and their de-regulation is found in several metastatic cancers.
Our laboratory consists of three to four postdoctoral fellows, a laboratory manager, and a staff scientist, along with a post-baccalaureate fellow. We are very interactive group and weekly Laboratory meetings within the PI laboratory, CDBL and within the Cancer Genetics & Signaling faculty (consisting of 19 PI laboratories at Frederick). We are also participants in the monthly Frog/Fish Interest Group in Bethesda with members from NIH, Georgetown University, and George Washington University.
Roles and Responsibilities
A postdoctoral position is available to study the role of Eph receptors, ephrin ligands, and Wnt signaling pathways in cell movement and morphogenesis. A combination of molecular, cell biological, and biochemical techniques are applied in the amphibian developmental and mammalian culture systems.
About You
A strong background in molecular, cellular, or developmental biology is required. Interested candidates should have a Ph.D. and/or an M.D. and have less than 5 years postdoctoral experience. Fellows from abroad would receive a J1 visa.
Application
Please send your CV, and contact information for three references by e-mail.
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