Post date: 3/11/19
Research in the laboratory of Yoh-suke Mukouyama is aimed at understanding the molecular control of branching network formation in organ development, with a particular emphasis on two major networks, the nervous and vascular systems, which share several anatomic characteristics, and are often patterned similarly in peripheral tissues including skin, heart, and gut. We have recently extended our research to unanticipated roles of tissue macrophages and microglia in neuronal and vascular development. Advanced whole-mount imaging techniques and genetic manipulations provide powerful tools to address these four independent but thematically interrelated projects studying fundamental questions of branching morphogenesis and patterning of these networks.
- Neuronal influence on vascular branching patterns
- Vascular influence on neuronal guidance
- Myeloid/Macrophage influence on vascular and neuronal development
We have a weekly one-on-one meeting to discuss recent data and ongoing issues, and outline a roadmap for ongoing projects, and have a weekly lab meeting/journal club to improve scientific communication and presentation skill. To present preliminary data and interact with experts in the NIH community, we have a weekly Center Seminar Series, a monthly trans-NIH Joint Angiogenesis Meeting, and a quarterly trans-NIH Developmental Biology Interest Group Workshop. We encourage fellows to interact with career consultants and advisors including the NIH Office of Intramural Training and Education and the NHLBI Office of Education.
Roles and Responsibilities
This position will offer a unique opportunity to work at the intersection of cardiovascular development, neuronal development, myeloid/macrophage biology and stem cell biology. We aim to have fellows focus on developing skills that will serve them as an independent investigator, including writing papers, giving talks, mentoring, collaborating and leading projects to fruition in academic medicine or industry.
About You
We seek a highly motivated candidate who has experience of working with molecular genetic tools, advanced imaging techniques, primary culture, and/or genome-wide profiling studies such as RNA-Seq and ChIP-Seq.
Candidates must have a Ph.D. or M.D./Ph.D. degree awarded within the past 3 years and a record of at least one first-author publication in a high-quality peer-reviewed international journal.
Application
Please send an e-mail to me (mukoyamay@mail.nih.gov) with a curriculum vitae and cover letter describing the following information:
- A brief description of candidate's past research projects
- What topics you are interested in the Mukoyama lab?
- What ideas and techniques you hope to bring to the Mukoyama lab?
- What is your career goal?
- The names of 3 references
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